Sophie caillat inserm
Sophie caillat inserm. caillat@inserm. Asier Saez-Cirion. Greatly variable graft lymphocyte turnover rates. By targeting the 4. grillot@inserm. 11Centre Hospitalier Universitaire Orléans. Sophie Caillat-Zucman, Laboratoire d’Immunologie, Hôpital Saint Jun 2, 2023 · CAR T cell therapy is an immunotherapy that is effective in treating blood cancer. Feb 2, 2018 · Introduction. Laurence Meyer. 2 Institut Curie, Université PSL, Inserm U932, Immunity and Cancer, Paris, France 3 Université Paris Cité, INSERM, CNRS, UMS Saint-Louis (US53/UAR2030), Paris, France Feb 5, 2018 · 11 Institut national de recherche médicale (INSERM) UMR1149, Center for Research on Inflammation, Paris Diderot University, Paris, France sophie. fr Search for more papers by this author Dec 23, 2008 · S. fr Oct 5, 2021 · Introduction. T cell repertoire of 26 patients with iPAH, hPAH or PVOD (11 transplanted) and 24 controls were . HLA evolutionary divergence (HED) between an individual’s HLA alleles is a continuous metric that quantifies the differences between each amino acid of two homologous alleles and reflects the breadth of the immunopeptidome presented to T lymphocytes. Independent. Sophie CAILLAT-ZUCMAN, Head INSERM U976 HIPI team 4 | Cited by 13,735 | of French Institute of Health and Medical Research (Inserm) | Read 308 publications | Contact Sophie CAILLAT-ZUCMAN. Sophie Caillat-Zucman, Laboratoire d’Immunologie, Hôpital Saint 5 INSERM U932, Université PSL, Institut Curie, Paris, France. # Julie Delyon 1 , Lucie Biard 2 , Marion Renaud 3 , Matthieu Resche-Rigon 2 , Jérôme Le Goff 4 , Stéphane Dalle 5 , Valentine Heidelberger 6 , Laetitia Da Meda 3 , Laurie Toullec 7 , Guislaine Carcelain 8 , Samia Mourah 9 , Sophie Caillat-Zucman 7 , Vincent Allain 7 , Maxime Battistella 10 , Céleste Lebbe 11 Jun 6, 2023 · TO THE EDITOR: Clonal evolution to myelodysplastic neoplasms/syndromes (MDSs) or acute myeloid leukemia represents the most serious late complication among patients with aplastic anemia (AA) and paroxysmal nocturnal hemoglobinuria (PNH). As CAR-T cells are entering advanced phases of clinical development, there is a need to develop universal, ready-to-use products using im … Feb 15, 2018 · ©nerthuz – adobestock . Caillat-Zucman. Dec 23, 2008 · Sophie Caillat‐Zucman, MD INSERM U561 Hôpital St‐Vincent de Paul 82 avenue Denfert‐Rochereau 75014 Paris France Tel: +33 1 4048 8249 Fax: +33 1 4048 8352 e‐mail: sophie. Nommée à ce poste en juin 2015, elle succédait alors à l’hématologiste Mauricette Michallet. Gastrointestinal stromal tumors (GIST) are the most frequent mesenchymal tumor of the gastrointestinal tract, with an annual incidence of around 10–20 cases per million. 1BB/CD3z (28BBz) or 28/CD3z (28z) junction area, we demonstrated that PCR assays can be applied to approved CD19 CAR T drugs. In the setting of type 1 diabetes (T1D), insulitic lesions are enriched for CD8 + T cells, which are held as the final mediators of islet destruction. Concordantly, preproinsulin (PPI)-reactive CD8 + T-cell clones can lyse β cells in-vitro (), and β-cell-reactive CD8 + T cells infiltrate the islets of T1D p May 17, 2021 · Sophie Caillat-Zucman. fr Search for more papers by this author Oct 10, 2005 · François Ghiringhelli, 1, 5 Cédric Ménard, 1 Magali Terme, 1 Caroline Flament, 1 Julien Taieb, 1 Nathalie Chaput, 1 Pierre E. In addition, they establish an early and efficient Sophie Caillat-Zucman,2,3,10,11 and Philippe Bousso1,10,11,12,* 1Institut Pasteur, Universite ´Paris Cite, INSERM U1223, Dynamics of Immune Responses Unit, E´quipe Labellisee Ligue Contre le Cancer, 75015 Paris, France 2Universite ´Paris Cite,H^opital Saint-Louis, AP-HP Nord, Laboratoire d’Immunologie, Paris, France Aug 30, 2022 · Background Organ transplant recipients are at high risk of viral infections but show lower humoral vaccine responsiveness than immunocompetent individuals. Sophie CAILLAT-ZUCMAN, Head INSERM U976 HIPI team 4 | Cited by 13,424 | of French Institute of Health and Medical Research (Inserm) | Read 302 publications | Contact Sophie CAILLAT-ZUCMAN Oct 12, 2017 · 2 Centre de Recherches sur l'Inflammation, Institut National de Recherche Médicale (INSERM) UMR1149, Université Paris Diderot, 75013 Paris, France. Feb 14, 2019 · Clara Malka-Ruimy, 1, † Ghada Ben Youssef, 1 Marion Lambert, 1 Marie Tourret, 1 Liana Ghazarian, 1 Albert Faye, 2 Sophie Caillat-Zucman, 1, 3, * and Véronique Houdouin 1, 4 Clara Malka-Ruimy 1 INSERM UMR1149, Centre de Recherche sur l'Inflammation, Université Paris Diderot, Paris, France Aug 15, 2023 · Sophie Caillat-Zucman. fr). Grandjean, 1 Florence Morin, 2 Catherine Thieblemont, 5 Sophie Caillat-Zucman, 2, 3 and Philippe Bousso 1 Loop is the open research network that increases the discoverability and impact of researchers and their work. sophie. Guerin, 1 Zacarias Garcia, 1 Ruby Alonso, 1 Fabrice Lemaître, 1 Alexander Beer, 1 Béatrice Corre, 1 Laurie Menger, 4 Capucine L. HIPI unit, created in 2019, is gathering two former Inserm units (U976 and U1126) and four research teams originating from three Inserm units (U1160, U1149, and U944) and two CEA units. Methods We retrospectively investigated the impact of HED on Oct 12, 2017 · We thank R. Reactivity of NK cells toward target cells is tightly regulated by the integration of signals from activating and inhibitory cell surface receptors, which ultimately determine the magnitude of NK cell-mediated cytotoxicity and cytokine production [1–4]. inserm. fr Highlights Hematopoietic stem cell transplant recipients have impaired response to SARS-CoV-2 vaccine HLA-DPB1 divergence in the donor is associated with low levels of anti-spike IgG Donor HLA-DPB1 homozygosity is associated with no SARS-CoV-2 vaccine response Villemonteix et al. Université Paris Descartes, Faculté de Médecine, Paris, France. 3 INSERM UMR976, Institut de Recherche St-Louis, Paris, France. Nov 8, 2016 · INTRODUCTION. Natural Killer (NK) cells are cytotoxic innate lymphoid cells that are involved in the elimination of infected cells and tumors. fr / +33 (0)1 57 27 67 26 L'Unité 976 HIPI « Immunologie Humaine, Pathophysiologie, Immunothérapie » créée en 2019, est un laboratoire de recherche sous double tutelle Inserm et Université de Paris. Although primary Sjögren’s syndrome (pSS) affects up to 0. University of Paris - INSERM U1016. A study conducted by an Inserm team led by Roberto Mallone at the Cochin Institute (Inserm, CNRS, Paris Descartes University) is calling into question the role long attributed to the thymus in selecting and eliminating white blood cells associated with type 1 diabetes and reveals that we are Secrétaire générale : Hubert GRILLOT / hubert. These authors contributed equally to this work. 5 INSERM U932, Université PSL, Institut Curie, Paris, France; 6 Laboratoire d'immunologie clinique & Centre d'investigation Clinique en Biothérapie (CIC-BT1428), Institut Curie, Paris, France; Correspondence to Professor Sophie Caillat-Zucman; sophie. Here, we analyzed the immunosuppressive effect of MAIT cells in an in vitro model of alloreactivity and explored their adoptive transfer in a preclinical xenogeneic GVHD model. Chevalier, Marion Lambert, Sophie Caillat-Zucman, Damien Sène & Cloé Comarmond Hôpital Fernand Widal, INSERM UMR-S 1144, Université Paris Feb 1, 2024 · Nana Talvard-Balland 1 , Marion Lambert 1 , Mathieu F Chevalier 1 , Norbert Minet 1 , Marion Salou 2 , Marie Tourret 1 , Armelle Bohineust 1 , Idan Milo 1 , Véronique Parietti 3 , Thomas Yvorra 4 , Gérard Socié 1 5 , Olivier Lantz 2 6 7 , Sophie Caillat-Zucman 1 8 Jun 21, 2021 · Methods. Daniel Scott-Algara. By closely investigating some of the immune cells generated during this therapy, known as CD4 T cells, scientists from the Institut Pasteur and Inserm, in collaboration with clinicians from the Paris Public Hospital Network (AP-HP), discovered that these cells are capable of remotely neutralizing tumor cells by Jul 27, 2024 · Jeanne Chauffier, Henri Berger de Gallardo, Mathieu F. 4 Centre Hépato-Biliaire, Hôpital Paul-Brousse, AP-HP, Université Paris-Saclay, FHU Hepatinov, 94800 Villejuif, France. 1 INSERM UMR-976 HIPI, Institut de Recherche Saint-Louis, Université Paris Cité, Paris, France. fr. Physiopathologie de l’autoimmunité Pr. 1–0. INSERM U25 and Service d' Immunologie Clinique, Hǒpital Necker, 161 Rue de Sevres, F-75015, Paris, France (Fax: 1430623 88)Search for more papers by this author Sep 20, 2016 · // Asma Beldi-Ferchiou 1, 2, 11 , Marion Lambert 1, 2 , Stéphanie Dogniaux 3 , Frédéric Vély 4, 5 , Eric Vivier 4, 5 , Daniel Olive 6 , Stéphanie Dupuy 1 , Frank Levasseur 1 , David Zucman 7 , Céleste Lebbé 8 , Damien Sène 1, 2, 9 , Claire Hivroz 4 , Sophie Caillat-Zucman 1, 2, 10 1 Institut National de Recherche Médicale (INSERM Olivier Lantz2,6,7 and Sophie Caillat-Zucman1,8*. , iScience 26 Dec 15, 2017 · Mucosal-associated invariant T (MAIT) cells are unconventional CD3<sup>+</sup>CD161<sup>high</sup> T lymphocytes that recognize vitamin B2 (riboflavin) biosynthesis precursor derivatives presented by the MHC-I related protein, MR1. Laurent Hocqueloux. Based on 2 experimental CAR T cell constructs, IL-1RAP and CS1, we designed 2 quantitative digital droplet (ddPCR) PCR assays. We investigate the reconstitution dynamics and functional role(s) of mucosal-associated invariant T cells (MAITs) after HSCT, and also consider their use as a source of universal cells to produce chimeric antigen receptor (CAR-MAIT) cells. Thus Loop is the open research network that increases the discoverability and impact of researchers and their work. We searched for an immune signature in the lung and peripheral blood of PAH patients. . 3 Service d'hématologie-greffe, Hôpital Saint-Louis, AP-HP, Université Paris Cité, 75010 Paris, France. Apr 25, 2016 · Introduction. 6 Laboratoire d'immunologie clinique & Centre d'investigation Clinique en Biothérapie (CIC-BT1428), Institut Curie, Paris, France. 1, 2 Most post-AA/PNH MDS cases present high-risk features, with chromosome 7 abnormalities and mutations in ASXL1, RUNX1, SETBP1, and RAS genes as the most Sophie Caillat-Zucman, MD INSERM U561 Hoˆpital St-Vincent de Paul 82 avenue Denfert-Rochereau 75014 Paris France Tel: 133 1 4048 8249 Fax: 133 1 4048 8352 Caillat-Zucman, Sophie,现任职于Inserm,曾任职于布里格姆妇女医院、Federation Nationale des Centres de Lutte Contre le Cancer等机构,个人H指数为53,累计发表论文217篇,论文总被引数累计9166次,主要研究方向涵盖医学、免疫学与微生物学、生物化学,遗传学和分子生物学、神经学等领域,在The Lancet、New England Journal Sophie Caillat-Zucman sophie. caillat@paris5. VISCONTI Study * E-mail: sophie. Prof. Etablissement Français du Sang, AP-HP, Hôpital Universitaire Robert Debré, Paris, France INSERM U944/CNRS UMR7212, Institut de Recherche Saint-Louis, Université de Dec 22, 2020 · Background Recognition of donor antigens by the recipient’s immune system leads to allograft rejection. fr May 19, 2023 · 2 INSERM UMR 976, Université Paris Cité, Institut de Recherche Saint-Louis (IRSL), 75010 Paris, France. 12 Laboratoire d'Immunologie, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France. 3 Laboratoire d'Immunologie, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, 75010 Paris, France. Feb 1, 2024 · Mucosal-associated invariant T (MAIT) cells were recently associated with tissue repair capacities and with lower rates of GVHD in humans. caillat-zucman@aphp. The presence of Ig deposits and tertiary lymphoid tissues (tLTs) connected to remodeled vessels in PAH lungs suggests lymphoid neogenesis as a critical step in maintaining immunity against local autoantigens. It is led by Jean-Christophe Bories, director. Author Contributions Asma Beldi-Ferchiou and Sophie Caillat-Zucman wrote the paper. ANRS PRIMO Cohort. Sophie Caillat-Zucman Laboratoire d’Immunologie, Hôpital Robert Debré et INSERM U986 sophie. O Hermine, X Mariette, PL Tharaux, M Resche-Rigon, R Sophie CAILLAT-ZUCMAN, Head INSERM U976 HIPI team 4 | Cited by 11,161 | of French Institute of Health and Medical Research (Inserm) | Read 265 publications | Contact Sophie CAILLAT-ZUCMAN Project managers: Sophie CAILLAT-ZUCMAN. 1 GIST are characterized by activating mutations in KIT or PDGFRA oncogenes, the key molecular drivers of the disease pathogenesis. University of Paris-Saclay - Institut Pasteur. Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. 1–3 On TCR engagement, MAIT Sep 20, 2016 · // Asma Beldi-Ferchiou 1, 2, 11 , Marion Lambert 1, 2 , Stéphanie Dogniaux 3 , Frédéric Vély 4, 5 , Eric Vivier 4, 5 , Daniel Olive 6 , Stéphanie Dupuy 1 , Frank Levasseur 1 , David Zucman 7 , Céleste Lebbé 8 , Damien Sène 1, 2, 9 , Claire Hivroz 4 , Sophie Caillat-Zucman 1, 2, 10 1 Institut National de Recherche Médicale (INSERM Mucosal associated invariant T cells (MAIT) are innate T lymphocytes that display a semiinvariant T cell receptor capable of recognizing bacteria derived riboflavin metabolites. 6% of the general population, few rigorous etiologic studies have focused on the initiating immunopathologic process occurring in the exocrine glands. Sophie Caillat-Zucman. Puig, 5 Sophie Novault, 1 Bernard Escudier, 2 Eric Vivier, 6 Axel Lecesne, 3 Caroline Robert, 3 Jean-Yves Blay, 7 Jacky Bernard, 8 Sophie Caillat-Zucman, 9 Antonio Freitas, 10 Thomas Tursz, 1 Orianne Wagner-Ballon, 4 Physiopathologie de l’autoimmunité Pr. In humans, their T cell receptor is composed of a Vα7. Sophie Caillat-Zucman, MD INSERM U561 Hôpital St-Vincent de Paul 82 avenue Denfert-Rochereau 75014 Paris France Tel: +33 1 4048 8249 Fax Dec 23, 2008 · Sophie Caillat-Zucman, MD INSERM U561 Hôpital St-Vincent de Paul 82 avenue Denfert-Rochereau 75014 Paris France Tel: +33 1 4048 8249 Fax: +33 1 4048 8352 e-mail: sophie. Sophie Caillat-Zucman is Head of the Saint-Louis Immunology Department, the largest in France with a unique activity in the field of organ and hematopoietic stem cell transplantation, and in CAR-T cell therapies. Université de Paris. INSERM U25 and Service d'Immunologie Clinique, Hǒpital Necker, Paris. They kill virally infected cells and are an important source of antiviral cytokines such as IFNc. A small revolution has taken place in the world of type 1 diabetes research. Corresponding Author. Using recipient and/or donor-specific monoclonal antibodies in combination with a pan-HLA class I mAb, the phenotypes and origins of intra-epithelial lymphocyte (IEL) and lamina propria lymphocyte (LPL) populations were investigated with multicolor flow-cytometry. The aims of this study are to determine MAIT cells frequency and phenotype in children with latent or active pulmonary Treatment of hematological malignancies by autologous T cells expressing a chimeric antigen receptor (CAR) is a breakthrough in the field of cancer immunotherapy. fr 1 INSERM UMR-976 HIPI, Saint Louis Research Institute, Université Paris Cité, Paris, France. Background In PAH, tertiary lymphoid tissues (tLTs) connected to remodeled vessels, Ig deposits in the lung, and circulating autoantibodies to vascular wall components, argue for a role of adaptive immune response and autoimmunity, beyond inflammation. Institut National de la Santé et de la Recherche Médicale (INSERM), U561, Hôpital St-Vincent de Paul, Paris, France. HLA evolutionary divergence (HED) quantifies the sequence differences between homologous HLA alleles and reflects the breadth of the immunopeptidome presented to T lymphocytes. Aims The presence of tLTs in the lung suggests lymphoid neogenesis as a critical step in maintaining immunity against local autoantigens. MAIT cells could contribute to the early control of infection with Mycobacterium Tuberculosis. Effect of tocilizumab vs usual care in adults hospitalized with COVID-19 and moderate or severe pneumonia: a randomized clinical trial. Mallone (INSERM U1016 Cochin Institute) for reviewing the paper. 2-Jα33/20/12 c … Liana Ghazarian, 1 Sophie Caillat-Zucman, 1, 2, * and Véronique Houdouin 1, 3 Liana Ghazarian 1 INSERM UMR1149, Centre de Recherche sur l’Inflammation, Université Paris Diderot, Paris, France Aug 27, 2014 · Jean Baptiste Haumonte, 1 , 2 Sophie Caillat-Zucman, 3 Florence Bretelle, 1 Marion Lambert, 3 Luc Lyonnet, 4 Annie Levy-Mozziconacci, 5 Catherine Farnarier, 6 Agostini Aubert, 7 Leon Boubli, 1 Laurence Camoin-Jau, 4 , 8 Françoise Dignat George, 2 , 4 and Pascale Paul 2 , 4 , * May 29, 2023 · Morgane Boulch, 1 Marine Cazaux, 1 Alexis Cuffel, 2, 3 Marion V. 2 Université de Paris Cité, Hôpital Saint-Louis, AP-HP Nord, Laboratoire d'Immunologie, Paris, France. fr; PMID: 16698443 1 Institut Pasteur, Université de Paris Cité, INSERM U1223, Dynamics of Immune Responses Unit, Equipe Labellisée Ligue Contre le Cancer, Paris, France. 2 Approximately 75–80% of GIST harbor a KIT mutation, most frequently in the May 5, 2023 · Further information and requests for resources and reagents should be directed to and will be fulfilled by the lead contact, Sophie Caillat-Zucman (sophie. Jun 6, 2024 · Sophie Ugolini, Research Director at Inserm and leader of the Neural Regulation of Immunity team at the Marseille-Luminy Immunology Centre (unit 1104 Inserm/Aix-Marseille University/CNRS). Mucosal-associated invariant T (MAIT) cells are innate-like T cells expressing a semi-invariant T-cell receptor (TCR) which recognizes microbial-derived riboflavin (vitamin B 2) precursors such as 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU) presented by MR1, a monomorphic major histocompatibility antigen (MHC) class-1 like molecule. Nestled in the heart of the Calanques National Park, on the campus of Aix-Marseille University, the Marseille-Luminy Immunology Centre can be proud to count Jul 7, 2013 · Introduction. Materials availability Feb 1, 2024 · 1 INSERM UMR-976 HIPI, Saint Louis Research Institute, Université Paris Cité, Paris, France. 2 days ago · 3 INSERM UMR976, Institut de Recherche St-Louis, Université Paris Cité, (AP-HP), Université Paris Cité, Paris, France sophie. fr Sophie Caillat-Zucman 1 Affiliation 1 AVENIR Team INSERM U561, Hôpital St-Vincent de Paul, Paris, France. Introduction Natural Killer (NK) cells are effectors of the rapidly acting antiviral innate immune system. We investigated whether or not HED of Dec 31, 2018 · Klaudia Kuranda 1 2 3 , Sophie Caillat-Zucman 4 5 , Sylvaine You 1 2 3 , Roberto Mallone 1 2 3 6 Affiliations 1 INSERM, U1016, Cochin Institute, Paris 75014, France. Olivier Lantz,2,8,9,10** Valérie Biran, 4** and Sophie Caillat-Zucman1,11 1Institut national de recherche médicale (INSERM) UMR1149, Center for Research on Inflammation, Paris Diderot University, Paris, France 2Institut Curie, PSL Research University, INSERM U932, Paris, France Mar 18, 2024 · Sophie Caillat-Zucman est responsable de l’équipe Réponses immunes chez l’hôte immunocompromis : tolérance versus GVHD au sein de l’unité Immunologie humaine, physiopathologie et immunothérapie (Hipi Lab, unité 976 Inserm/Université Paris Cité), à l’hôpital Saint-Louis à Paris. 7 INSERM UMR976, Human Immunology, Pathophysiology and Immunotherapy, Université de Paris, Paris, France sophie. S Caillat-Zucman 1 Affiliation 1 Institut National de la Santé et de la Recherche Médicale (INSERM), U561, Hôpital St-Vincent de Paul, Paris, France. caillat-zucman{at}aphp. Jun 14, 2018 · Par décret du Président de la République en date du 11 juin 2018, la professeur Sophie CAILLAT-ZUCMAN est reconduite à la présidence du conseil d’administration de l’Agence de la biomédecine, pour une durée de 3 ans. xstr dzppml iesqy dfq fnhuj wki gnagx ibbiuhw lhyiq smrmw